Program

  March 19, 2012  
OPENING    
9:00-11:00 Registration  
11:00-11:45 Welcome Speeches  
11:00-11:15 Marion Guillou, President INRA, France  
11:15-11:30 Pascale Briand, General Director, ANR, France  
11:30-11:45 Rudolf Strohmeier, Deputy Director General, DG Research and Innovation, European Commission  
KEYNOTE Chair: Julian Davies, UBC, Canada  
11:45-12:30 S.D.Ehrlich, INRA, France  
  Lessons from the MetaHIT project  
12:30-14:00             Lunch - Poster Session  
APPROACHES TO MICROBIOME ANALYSIS Chair: Soren Brunak, CBS Denmark Technical University, Denmark  
14:00-14:30 Rob Knight, University of Colorado, USA  
  Sources of variation in the human microbiome  
14:30-15:00 Li Junhua, BGI Shenzhen, China  
  Improvement of microbial gene catalog construction  
15:00-15:30 Karen E. Nelson, JCVI, USA  
  Reference genomes for the study of the Human Microbiome  
15:30-16:00 H. Bjorn Nielsen, DTU, Denmark  
  MetaGenomic Species: adding structure to metagenomics data  
16:00-16:15 Mathieu Almeida, INRA, France  
  From "meta-genomic species" to high quality draft genomes  
16:15-16:30 Mircea Podar, Oak Ridge National Laboratory - Univ. of Tennessee, USA  
  Uncovering the dark matter of the human microbiota through high throughput single cell genomics and targeted pangenomics  
DATA ORGANISATION & INTERPRETATION Chair: Lita Proctor, National Institutes of Health, USA  
17:00-17:30 Owen White, DACC, USA  
  The Human Microbiome Project analysis infrastructure  
17:30-18:00 Jens Nielsen, Chalmers University of Technology, Sweden  
  Prospects for systems biology and modeling of the gut microbiome  
18:00-18:30 Mani Arumugam, EMBL, Germany  
  Towards petabase metagenomics : challenges and roadblocks ahead  
18:30-18:45 Dan Knights, University of Colorado, USA  
  Human‐associated microbial signatures: Examining their predictive value  
19:00-21:00 Wine and Cheese Buffet - Poster Session  
  March 20, 2012  
MICROBIOME IN HEALTHY INDIVIDUALS 1 Chair: Jane Peterson, National Institutes of Health, USA  
9:00-9:30 Dirk Gevers, The Broad Institute, USA  
  Baseline for a healthy human microbiome  
9:30-10:00 Mihai Pop, University of Maryland, USA  
  Can we and should we assemble metagenomes?  
10:00-10:30 Curtis Huttenhower, Harvard School of Public Health, USA  
  Reducing microbial unemployment: functional roles for the microbiome in health and disease  
10:30-10:45 Masahira Hattori, University of Tokyo, Japan  
  Metagenomics of Japanese gut microbiomes  
MICROBIOME IN HEALTHY INDIVIDUALS 2 Chair: Maria Giovanni, National Institutes of Health, USA  
11:15-11:45 Kristine Wylie, Washington University, USA  
  Novel Bacterial Taxa in the Human and Vervet Microbiomes  
11:45-12:15 Paul W. O'Toole, APC UCC, Ireland  
  Diet-health-microbiota interactions in older persons  
12:15-12:30 Christian Hoffman, University of Pennsylvania, USA  
  Long term dietary patterns shape gut microbial enterotypes  
12:30-14:00 Lunch - Poster Session  
13:15-13:45 Seminar: Power calculations for designing microbiome experiments  
MICROBIOME IN DISEASE 1 Chair: Karsten Kristiansen, University of Copenhagen, Denmark  
14:00-14:30 Oluf Pedersen, Copenhagen University, Danemark  
  Deep metagenomic sequencing demonstrates marked differences in the gut microbiome between lean and obese people: evidence from the MetaHit obesity study  
14:30-15:00 Karine Clement, INSERM, France  
  Gut metagenome: clinical investigation studies  
15:00-15:30 Liping Zhao, SJTU, China  
  “Microbiome-wide association studies, MiWAS” for dissecting the role of gut microbiota in metabolic syndrome, from animal models to human trials  
15:30-16:00 Wang Jun, BGI Shenzhen, China  
  A Metagenome-Wide Association Study of gut microbiota identifies markers associated with Type 2 Diabetes  
16:00-16:15 Li Lanjuan, Zhejiang University, China  
  The intestinal dysbiosis and its contribution to NAFLD in human and the high-fat induced rats  
16:15-16:30 Kjersti Aagaard, Baylor College of Medicine, USA  
  A comprehensive metagenomic catalogue of microbiota across body sites in primates: a high fat maternal diet alters the offspring microbiome to 1 year of age  
MICROBIOME IN DISEASE 2 Chair: Per Brandtzaeg, Oslo University Hospital, Norway  
16:45-17:15 Francisco Guarner, Hospital Vall d'Hebron, Spain  
  Distortion of the gut microbial ecosystem in patients with ulcerative colitis  
17:15-17:45 Brandi Cantarel, University of Maryland, USA  
  Identification of Crohn’s signatures in the human gut microbiota by meta-omics  
17:45-18:15 James Versalovic & Emily Hollister, Texas Children's Hospital, USA  
  Network analysis reveals altered community structure in the fecal microbiota of children with irritable bowel syndrome  
18:15-18:45 Jacques Ravel, University of Maryland, USA  
  Transcriptional dynamics of the vaginal microbiome  
18:45-19:15 Melody Slashinski, Baylor College of Medicine, USA  
  Ethical, legal, and social dimensions of human microbiome research  
19:45                         Gala Dinner  
  March 21, 2012  
MICROBIOME MODULATION Chair: Annick Mercenier Nestlé Research Center, Switzerland  
9:00-9:30 Muriel Derrien, Danone Research, France  
  Impact of consumption of a fermented milk product on gut microbiota stability and functinality in ulcerative patients  
9:30-10:00 David A. Relman, Stanford University, USA  
  Stability and resilience in the human microbiome  
10:00-10:30 Willem de Vos, Wageningen University, The Netherlands  
  From associations to causality: Effect of treatments targeting the human intestinal microbiome  
10:30-10:45 Paul Cotter, University College Cork, Ireland  
  Modulation of the gut microbiota; antibiotics vs. bacteriocins  
FUNCTIONS OF MICROBIOME 1 Chair: Emmanuelle Maguin, INRA, France  
11:15-11:45 Joel Dore, INRA, France  
  Screening of Metagenomic Clones  
11:45-12:15 B. Brett Finlay, University of British Columbia, USA  
  The role of microbiota in enteric and allergic diseases  
12:15-12:30 Marion Leclerc, INRA, France  
  Riboflavin production by a metagenomic clone from the human ileum mucosa: a new role for Faecalibacterium prausnitzii in vivo?  
12:30-14:00                 Lunch - Poster Session  
FUNCTIONS OF MICROBIOME 2 Chair: Baghi Singh, Canadian Institutes of Health Research, Canada  
14:00-14:30 Stephen M. Collins, McMaster University Medical Center, Canada  
  The Influence of the intestinal microbiota on the gut-brain axis  
14:30-15:00 Martin J. Blaser, NYU, USA  
  Effects of early-life antibiotics on murine microbiota, developmental phenotypes and immunity  
15:00-15:15 James Goedert, National Cancer Institute NIH, USA  
  Fecal microbial determinants of fecal and systemic estrogens  
15:15-15:30 Iradj Sobhani, UPEC-Paris XII, France  
  Putative role of gene mutation and environment in colon canrcinogenesis: role of microbiota  
MICROBIOME DATA CHALLENGES    
15:30-16:15 Peer Bork, EMBL, Germany  
  Complexity and individuality of human gut microbiomes  
MICROBIOME FUTURE Panel Discussion on the Future of Human Microbiome Research  
     
16:45-18:30                 Debate moderator: Ed Yong, UK  
     
  Funding agencies...  
     
  Patrik Kolar, EC, Belgium  
  Marc Ouellette, CIHR, Canada  
  Lita Proctor, NIH, USA  
     
  ...Industry  
     
  Pierre Bélichard, Entérome, France  
  Christian Bréchot, Institut Mérieux, France  
  Johan Van Hylckama Vlieg, Danone Research, France  
     
  ...Ethical & social issues...  
     
  Lucy Hoareau, UNESCO  
  Richard Sharp, Cleveland Clinic, USA  
     
     
18:30 CLOSURE